Akoya pearls are generally the most fragile cultured pearls because of their thin nacre; an Akoya is rated good quality at just 0.15 mm of nacre, and Akoya are almost always treated in some way. Good Australian South Sea pearls carry at least 2 mm of nacre on average. That thick, natural nacre responds well to skin oils, but being calcium carbonate it is softer than diamond and will etch on contact with acids — the same chemistry that attacks tooth enamel — so keep them clear of vinegar, citrus and harsh cleaners.
Natural Australian South Sea pearls are rarely found in the wild today, but a well-grown cultured pearl is virtually indistinguishable from those natural ancestors — both are real nacre laid down by the same species.
For more, read South Sea pearls: how to buy.